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Open reading frame: killer whales, dragonflies & publication bias
Open Reading Frame brings together a selection of recent publication highlights from elsewhere in the open access ecosystem. This week we take a look at the past few weeks in biology. Menopausal...
View ArticleInvestigating heterogeneity in acute myeloid leukemia
Drug resistance to cancer treatment is a major problem that clinicians and patients are facing. Genomic heterogeneity of cancer cells has emerged as critical to the effectiveness of treatment; varying...
View ArticleMechanisms linking excess body weight & cardiometabolic diseases
Excess body weight is a major risk factor leading to cardiometabolic diseases. These diseases are among the leading causes of death, therefore heightening the importance of understanding the molecular...
View ArticleModelling cancer with patient-derived xenografts: how accurate are they?
The necessity for clinically accurate models of human cancer is clear, with the main concern being to recapitulate the corresponding human tumour as closely as possible with as little divergence in the...
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Open reading frame: kidney disease, tuberculosis & childhood obesity
Open Reading Frame brings together a selection of recent publication highlights from elsewhere in the open access ecosystem. This week we take a look at the past few weeks in medicine. Understanding...
View ArticleGene expression heterogeneity in chronic lymphocytic leukaemia
Genetically identical cells, even within the same tissue, are often observed to have different levels of gene expression. So what effect does it have on the individual? Once seen as random ‘noise’,...
View ArticleThe movement of DNA from one species to another
The movement of genetic material between different species, named horizontal gene transfer (HGT), is well-known in single-celled organisms such as bacteria. However, the process is less well...
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Open reading frame: baboons, p-values & mitochondrial function
Open Reading Frame brings together a selection of recent publication highlights from elsewhere in the open access ecosystem. This week we take a look at the past few weeks in biology. Social...
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Open reading frame: Ebola drugs, fracture healing & antithrombotics
Open Reading Frame brings together a selection of recent publication highlights from elsewhere in the open access ecosystem. This week we take a look at the past few weeks in medicine. Early...
View ArticleThe possibilities of public RNA-seq data: identifying genetic variants
Genetic variants that affect gene expression levels can be identified using the fundamental technique, RNA-sequencing. This is achieved by one of two commonly used methods; expression quantitative...
View ArticleEscaping the immune system: tumor and immune cell interactions
Despite the fact that our immune systems are capable of recognising and eliminating cancer cells, in return, cancer cells have developed mechanisms that allow them to escape from our immune system...
View ArticleAssessing trends in healthcare interventions across Zambia
A major objective of many health systems worldwide is to ensure that all people obtain the high-quality health services they need without risk of financial hardship. Achieving this universal health...
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Open reading frame: infection, cancer & predicting kidney disease
Open Reading Frame brings together a selection of recent publication highlights from elsewhere in the open access ecosystem. This week we take a look at the past few weeks in medicine....
View ArticleHost-microbe interactions leading to inflammation following colectomy
Pouchitis is an inflammatory condition which commonly occurs in patients that have undergone a colectomy followed by ileal pouch-anal anastomosis (IPAA). IPAA is the surgical creation of an artificial...
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Open reading frame: chimps, climate and radioactive frogs
Open Reading Frame brings together a selection of recent publication highlights from elsewhere in the open access ecosystem. This week we take a look at the past few weeks in biology. Female chimps...
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